Abstract

Describe method describe the synthesis of Curcumin-3,4-dihydropyrimidinones by using green reaction profile. Substituted aromatic aldehydes, Urea and (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (Curcumin) added to PEG-400 as solvent in presence of heterogeneous catalyst Silica-Chloride and exposed to microwave at 600W. During reaction care was taken to avoid overheating by cutting microwave with definite time interval. After completion of reaction, reaction mass transfer to ice cold water and extracted with ethyl acetate to obtained crude product. Hot ethanol used for crystallization to get pure product. Propose reaction method is expendious, cost effective. Non requirement of column chromatography for purification is another significant advantage of present method.