Abstract

The current study examined the phytochemical makeup and antioxidant capacity of Annona reticulata leaf extracts in ethanol and water. Phenolics (98.14 mg/g), alkaloids (78.34 mg/g), flavonoids (53.71 mg/g), terpenoids (79.21 mg/g), and saponins (24.69 mg/g) were found to be more abundant in the ethanolic extract than in the aqueous extract (76.83, 56.74, 44.21, 4.21, and 21.49 mg/g, respectively), according to quantitative analysis. Both extracts exhibited concentration-dependent ferric reducing power and free radical scavenging, with the ethanolic extract exhibiting the highest antioxidant activity as measured by the DPPH and FRAP experiments. Several bioactive phytoconstituents that are responsible for the observed antioxidant effects were confirmed to be present by LC-MS profiling.