Abstract

Densities and viscosities of the non-steroidal anti-inflammatory drug ketorolac tromethamine were measured in aqueous media
over a molality range of 0.02–0.10 mol/kg. Measurements were performed in pure water as well as in aqueous potassium chloride
and α-lactose monohydrate systems at seven temperatures between 288.15 K and 318.15 K under atmospheric pressure. The
experimental data were employed to evaluate relative viscosity, Jones–Dole coefficients, temperature dependence of viscosity
parameters, and activation thermodynamic quantities associated with viscous flow. These derived parameters were used to
elucidate the nature of solute–solvent and solute–co-solute interactions and their variation with temperature. The influence of
electrolytic and non-electrolytic cosolutes on hydration behavior and solution structure was also examined