Abstract

The aim of the present study was to develop and evaluate liposomal hydrogel of mupirocin as a diabetic wound
dressing. Liposomal hydrogel as a wound dressing provides a barrier that effectively prevents the
contamination of the wound and further progression of infection to deeper tissues. Hydrogels combine the
features of moist wound healing with good fluid absorbance. Liposomes were developed by using different
ratios of Phospholipon 90H and cholesterol and the hydrogels was developed by using oxidized alginate and
gelatin. Liposomes prepared were then incorporated into the hydrogels. The formulations were characterized by
FT-IR and DSC for drug and polymer compatibility and surface morphology was studied by SEM. Liposomal
hydrogel were evaluated for their size, shape, encapsulation efficiency and for in vitro studies. The FT-IR and
DSC confirmed the absence of any drug polymer interaction. The average size of liposomes was found to be in
range of 708.21-802.33 nm and shape was found to be spherical. The maximum encapsulation efficiency was
found to be 69.13%. The in vitro release profile of liposomal hydrogel formulation LH6 was found to give
sustained release of drug. The stability study confirmed that the formulation prepared were stable.