Abstract

Copolymer of N-vinylpyrrolidone (NVP) and Acrylic acid (AA) was prepared by using hydrogen peroxide as
initiator in Tetrahydrofuran medium at 45oC under inert atmosphere. Synthesized copolymer was characterized
by FTIR, H1NMR and C13NMR. Copolymer was grafted with N-diethylaminoethanol through Acrylic acid group
to form an ester. The antibacterial properties of copolymer and its graft was investigated against four bacterial
strains i.e., Gram-ve Klebsiella aerogenes NCIM-2098, Pseudomonas desmolyticum NCIM-2028, and
Escherichia coli NCIM-5051 and Gram +ve bacteria like Staphylococcus aureus NCIM-5022. At 150 μg of
copolymer dose antibacterial activity was screened in agar media by well diffusion method. All the four
bacterial pathogens exhibited significant antibacterial activity in agar well diffusion method when compared
with the positive control.