Abstract

Natural products have long been a source of therapeutic agents. This study focuses on the natural product-inspired design and
synthesis of new chalcone derivatives using eco-friendly protocols in organic synthesis. The molecular hybridization approach is
adopted for designing the new chalcone derivatives by combining the Curcumin pharmacophoric group and chalcone functionality.
The Organocatalytic synthetic route has been developed for the synthesis of Chalcone derivatives by using piperidine as an
organocatalyst. The synthesized molecules were fully characterized by spectroscopic and spectrometric data. Emphasis is placed
on the green chemistry approach to minimize environmental impact and preparation of pharmacologically important molecules.
The synthesized compounds were further found to be antimicrobial and antifungal agents. This research highlights the potential
of natural products in drug discovery, particularly in the development of new treatments for various diseases.