Abstract

The objective of the study was to formulate and evaluate polymeric micelles (PMs) containing rosuvastatin
calcium (RC), an antilipidemic agent by thin-film hydration technique. PMs were prepared by thin-film hydration
technique. Historical data design suggested the optimum amounts of 3 mg of RC and 60 mg of Pluronic F127,
and predicted particle size (nm), drug loading (DL) (%), and encapsulation efficiency (EE) (%) were 14.11 nm,
19.98%, and 95.5%, respectively. Particle size, DL, and EE obtained for the optimized formulation was 15.01 nm,
20.23%, and 94.03%, respectively. Scanning electron microscopy image showed smooth surfaced spherical
micelles. Percentage cumulative drug release from the optimized formulation (F7) was 97.24% for 12 h. The
release kinetics for most of the formulations indicated that drug release followed Korsmeyer–Peppas model and
non-Fickian diffusion mechanism. F7 indicated that it was stable for 3 months. It can be concluded that RC PMs
formulation has significantly prolonged the release of the drug up to 12 h. Drug was successfully formulated into
sustained release PMs by thin-film hydration technique.