Abstract

An efficient enantio- and diastereoselective synthesis of substituted pyrrolidines have been reported using tartaric acid as an
organocatalyst through [3+2] cycloaddition of azomethine ylides (N-alkylidene glycine esters) and diploarophiles in good-
to-excellent yields. We have also used di-p-toluoyl-L-tartaric acid (DTTA) (30% mmol) as an organocatalyst which gives
[3+2]-dipolar cycloaddition product along with aza-Michael product by the reaction of dipolarophiles on cycloaddition product.
However, DTTA (5% mmol) afforded cycloaddition product as a major product.