Synthesis of 1-acetyl- 5-Substitutedaryl-3- [5-(5’-Methoxy-3-Indomethyl)-2-Amino-1, 3, 4-Oxadiazol-2-N-yl] - 2-Pyrazoline Derivatives as Potent Antiinflammatory Agent
Anil Kumar, Nitin Kumar, Surekha Kannaujia*
DOI: 10.22607/IJACS.2023.1102012
Volume 11, Issue 2 | Pages: 143-148
Abstract
When 5-(5-methoxy-3-indomethyl)- -1,3,4-oxadiazol- 2-amino substituted chalcones (5a-5e) undergo cyclisation
in presence of 99% hydrazine hydrate and few drops of glacial acetic acid and refluxed for 12 h, a novel series of
1-acetyl- 5-substitutedaryl-3- [5-(5’-methoxy-3-indomethyl)-2-amino-1,3,4-oxadiazol-2-N-yl]- 2-pyrazoline can be synthesized.
These compounds were characterized by IR, 1HNMR spectroscopy and screened for their promising anti-inflammatory activity.
Keywords
Oxadiazol Indole Chalcones Pyrazoline anti-inflammatory activity.References
No references available for this article.
Citation
Anil Kumar, Nitin Kumar, Surekha Kannaujia*. Synthesis of 1-acetyl- 5-Substitutedaryl-3- [5-(5’-Methoxy-3-Indomethyl)-2-Amino-1, 3, 4-Oxadiazol-2-N-yl] - 2-Pyrazoline Derivatives as Potent Antiinflammatory Agent. J Appl Pharm Sci. 2023; 11(2):143-148.