Abstract

iazepines are a class of nitrogen-containing heterocycles that have a seven-membered ring structure that includes two atoms of
nitrogen. Chalcone-based diazepine moieties have attracted significant interest from researchers due to their increased pharmacological,
biological, and therapeutic abilities. The present research included the synthesis of three new diazepine derivatives by the reaction
between 1,2-diaminobenzene and three distinct chalcone derivatives. The produced compounds underwent characterization
using 1HNMR and Fourier-transform infrared spectroscopies. The diazepines that were obtained were subjected to screening for
antibacterial activity against Escherichia coli, Pseudomonas, and Bacillus subtilis. The findings revealed that derivative F exhibited
the most potent action against E. coli and B. subtilis, while derivative D showed the greatest activity specifically against B. subtilis.